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2009 ASCO Weekend Update
May 31, 2009
Key Findings
-BSI-201 (SNY) & Olaparib (AZN) for Breast Cancer - PARP inhibitors showcased at ASCO produce striking results in difficult to treat metastatic breast cancer.
-NSCLC Maintenance (Tarceva, Avastin, Alimta) – While Alimta shows survival advantage over Tarceva, doctors skeptical of need for maintenance therapy and do patients live longer and/or live better?
-Avastin (Roche) for Adjuvant Colorectal Cancer - Avastin fails in adjuvant setting with unexplained transient benefit in DFS. AVANT study result still to come.
-Epratuzumab (IMMU) for Non-Hodgkin's Lymphoma (NHL) - Very encouraging phase II results in CD 22 positive DLBCL disease. Enthusiastic anticipation for phase III is high.
-Biovaxid Vaccine (ABPI) for Non-Hodgkin's Lymphoma (NHL) - Shortcomings in enrollment and trial design hamper positive outcome of the first phase III trial. However, additional study of the drug warranted.
-MDV3100 (MDVN) for Prostate Cancer - Strong efficacy data, seizures needs to be monitored in phase III, though low dose may be free of them.