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    SAMPLE TARGET PROFILE
(Data Shown as of 09/14/05)

Thrombin
10-Year Revenue Outlook: U.S.  Worldwide
 
Drugs:
Drug Lead Company Phase   (sort) Indication  (sort) Est. Approval Date Likelihood of Approval Peak Potential U.S. Revenue (M)
Angiomax The Medicines Company (MDCO) Approved (Clinical Detail) Percutaneous Coronary Interventions (PCIs) for Stable Angina 12/00 100% (Same As Avg.) $ 98.5
Angiomax The Medicines Company (MDCO) III (Clinical Detail) Coronary Artery Bypass Graft (CABG) 10/06 72% (5% Above Avg.) $ 39.2
Angiomax The Medicines Company (MDCO) III (Clinical Detail) Peripheral Arterial Disease N/A 74% (7% Above Avg.) $ 52.6
Angiomax The Medicines Company (MDCO) Approved (Clinical Detail) Acute Coronary Syndrome (ACS) 12/00 100% (Same As Avg.) $ 205.1
Angiomax The Medicines Company (MDCO) III (Clinical Detail) Cardiac Valve Surgery 10/06 70% (3% Above Avg.) $ 13.4
Argatroban Encysive Pharmaceuticals (ENCY) Approved (Clinical Detail) Heparin-Induced Thrombocytopenia (HIT) 06/00 100% (Same As Avg.) $ 238.8
Argatroban Encysive Pharmaceuticals (ENCY) Suspended (Clinical Detail) Ischemic Stroke N/A N/A N/A
ATryn GTC Biotherapeutics, Inc. (GTCB) III (Clinical Detail) Anticoagulation N/A 67% (Same As Avg.) N/A
AZD0837 AstraZeneca PLC (AZN) II (Clinical Detail) Venous Thromboembolism (VTE) N/A N/A N/A
Exanta AstraZeneca PLC (AZN) III (Clinical Detail) Venous Thromboembolism (VTE) N/A 55% (12% Below Avg.) $ 113.3
Exanta AstraZeneca PLC (AZN) Suspended (Clinical Detail) Dysrhythmia (Arrhythmia) N/A 1% (1% Above Avg.) $ 321.5
Flolan GlaxoSmithKline plc (GSK) Approved (Clinical Detail) Pulmonary Arterial Hypertension (PAH) 09/95 100% (Same As Avg.) N/A
Refludan Pharmion Corporation (PHRM) Approved in Europe (Clinical Detail) Heparin-Induced Thrombocytopenia (HIT) N/A N/A N/A
rh Thrombin ZymoGenetics, Inc. (ZGEN) II (Clinical Detail) Hemostasis N/A 32% (2% Above Avg.) N/A
 
Description: The fundamental clotting enzyme that converts fibrinogen to fibrin after a long series of molecular events initiates blood clot formation. Interference with its action has an anticoagulant effect.
 
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