Amyloidosis is a rare disorder that occurs when an abnormal protein, known as amyloid, is deposited in the organs and tissues. The amyloid proteins misfold and accumulate as insoluble amyloid fibrils, generally in the extracellular space. These protein aggregates damage organs and tissues, can affect more than one organ at the same time, and affect different tissues and organs in different individuals. Amyloidosis most frequently affects the heart, kidneys, liver, nervous system, and digestive tract. The severity of amyloidosis and its symptoms depend on the tissues and organs affected. 

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