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Datamonitor Healthcare Oncology Disease Analysis: HR+/HER2- Breast Cancer

February 06, 2020

Hormone receptor-positive (HR+) is the most common breast cancer subtype, with approximately 70% of breast cancers presenting with overexpression of estrogen receptors, progesterone receptors, or both. Overexpression of the hormone receptors allows estrogen and progesterone to drive tumor growth and proliferation. Therefore, endocrine therapy remains the standard treatment for advanced patients with HR+/human epidermal growth factor receptor 2-negative (HER2-) breast cancer.

Worldwide, breast cancer is the second most common cancer and the fifth leading cause of cancer-related deaths regardless of gender. In the US, breast cancer is the most common cancer in women and the fourth leading cause of cancer-related deaths, regardless of gender, behind lung cancer, colorectal cancer, and pancreatic cancer.

CDK4/6 inhibitors remain the standard treatment for advanced and metastatic HR+/HER2- patients. Datamonitor Healthcare expects their uptake to increase significantly over the forecast period as all three are projected to receive strategic label expansions into the adjuvant treatment setting for early-stage HR+/HER2- breast cancer patients.

This Datamonitor Healthcare report contains a Disease Analysis module.
Indications Covered: Breast Cancer
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