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Datamonitor Healthcare CV&Met Disease Analysis: Anemia in Chronic Kidney Disease

June 07, 2022

The anemia in chronic kidney disease (CKD) market has struggled as usage of high-selling, standard-of-care, injectable erythropoiesis-stimulating agents (ESAs) has declined, especially in the US, due to strict cost controls and an increased risk of CV events when targeting higher Hb levels, which has led to the use of lower Hb targets and more caution when deciding to initiate drug treatment. Biosimilars have also taken their toll, particularly in Europe, where biosimilar short-acting ESAs have taken a majority share of usage. The first biosimilar in the US, Retacrit, was only approved in 2018, but quarterly sales suggest it may be reaching a plateau. The ESAs could lose further share to the oral hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitors, which are more convenient in non-dialysis patients, reduce the dose of IV iron needed, and have non-inferior efficacy. 

This Datamonitor Healthcare report contains a Disease Analysis module.

Indications Covered: Anemia
Anemia Due to Chronic Renal Failure, Dialysis-Dependent
Anemia Due to Chronic Renal Failure, Dialysis-Independent
Renal Disease / Renal Failure
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