Datamonitor Healthcare Oncology Disease Analysis: Renal Cell Carcinoma (RCC)

July 09, 2021

The majority (75%) of renal cell carcinoma (RCC) cases have a clear cell histology (ccRCC), to which most first-line treatment regimens are specialized. The next most common histology is papillary RCC, comprising 15% of RCCs. 

The most prominent drug class in RCC currently is tyrosine kinase inhibitors (TKIs). While Nexavar inhibits both intracellular and cell surface kinases, other agents (Sutent, Votrient, Lenvima, Cabometyx, and Inlyta) block members of the receptor tyrosine kinase (RTK) superfamily associated with angiogenesis and tumor cell proliferation, most notably VEGFR and PDGFR. In addition to targeting VEGFR/PDGFR, Cabometyx targets the RTKs MET and AXL. Inlyta and Tivopath, on the other hand, are specific for members of the VEGFR family. 

This Datamonitor Healthcare report contains a Disease Analysis module.

Indications Covered:

Renal Cell Cancer (RCC)