The majority (75%) of renal cell carcinoma (RCC) cases have a clear cell histology (ccRCC), to which most first-line treatment regimens are specialized. The next most common histology is papillary RCC, comprising 15% of RCCs. 

Nearly all pharmacological interventions are administered in metastatic RCC. Sutent or Keytruda may be prescribed as a postoperative adjuvant therapy in locoregional disease, but the typical approach is nephrectomy alone. Welireg is another therapy recently approved for advanced disease, but is limited to treating patients with germline loss of function mutations in the tumor suppressor gene von Hippel-Lindau (VHL). 

This Datamonitor Healthcare report contains a Disease Analysis module.