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Datamonitor Healthcare CV&Met Disease Analysis: Hemophilia
November 20, 2020
Hemophilia is a rare, inherited X chromosome-linked bleeding disorder in which deficiencies in clotting factors prevent blood from clotting normally. Injuries therefore result in prolonged periods of bleeding. There are two types of hemophilia, A and B, with similar signs and symptoms but different genetic defects. Hemophilia A, or classic hemophilia, is caused by a mutation of the clotting factor VIII (fVIII) gene, while hemophilia B, also known as Christmas disease, is a mutation of the clotting factor IX (fIX) gene. Hemophilia A comprises 80– 85% of hemophilia cases, with hemophilia B making up the remaining 15–20%.
Hemophilia is predominantly a congenital condition that mainly affects males. Since the disorder is caused by an X-linked recessive allele, the disorder is more prevalent in males, who cannot compensate with a second functional allele. The disorder is less common in females because there is a low likelihood of inheriting two X chromosomes with faulty hemophilia genes. Females with a single faulty gene are asymptomatic; however, they still remain carriers and can pass on the mutated gene to their offspring.
This Datamonitor Healthcare report contains a Disease Analysis module.
Hemophilia A and B - General Clotting Products
Von Willebrand Disease